WE THE PEOPLE WARN MODI, IMMEDIATELY STOP TAKING DONATIONS FROM KOSHER VACCINE LOBBY..
WORK FOR BHARATMATA, NOT YOUR JEWISH MASTERS.
CHILDLESS MOSI, IF YOU DISREGARD THIS WARNING , YOU MAY HANG FOR IT .. RUNNING AWAY TO ISRAEL AFTER YOU LOSE POWER WILL NOT SAVE YOU..
VACCINOSIS IS THOUSANDS OF TIMES WORSE THAT COVID DISEASE — THE TERRIBLE AUTO IMMUNE EFFECTS WILL BE SEEN ONLY AFTER 20 YEARS.
WHEN MARGARET THATCHER STARTED FEEDING COWS IN BRITAIN WITH WASTE MEAT WITH REAGAN’S CONNIVANCE ( BOTH WERE DEEP STATE AGENTS ) I HAD WARNED BOTH BY A MESSAGE FROM SHIP—DON’T DO IT..
I WARNED “ YOU WILL HAVE TO EXTERMINATE 100% OF YOUR COWS AND THEN CREMATE THE CARCASSES. IF YOU BURY , THEN YOUR GROUND WATER WILL BE CONTAMINATED BY PRIONS“
HOW RIGHT I WAS !
WHAT HAPPENED TO ALL THE THINKERS OF THE PLANET?
COWS HAVE A DIGESTIVE SYSTEM WHICH CONVERTS GREEN GRASS ( ON ORGANIC SOIL ) TO COPIOUS WHITE MILK..
THE SYSTEM CANNOT HANDLE MEAT AND THAT TOO WASTE COW ENTRAILS.. IT CANT EVEN HANDLE THE OIL CAKES FED TO THEM.. COWS DON’T NEED OIL CAKE SUPPLEMENTS..
IT FORCED THE COW TO BE A CANNIBAL. GOD DOES NOT ALLOW THIS.
AND IMAGINE BRITAIN HAD TO EXTERMINATE 100% OF THEIR COWS.
http://ajitvadakayil.blogspot.com/2013/12/shocking-legacy-of-mad-cow-disease-capt.html
https://www.youtube.com/watch?v=Ni5a_Shlh5M
https://d28e2b5z7p5q0k.cloudfront.net/news/uk-farmer-heartbroken-more-cows-be-killed-after-bse-case
INDIAN HUMPED COWS HAVE A BETTER DIGESTINE SYSTEM , THE HUMP HAS A SURYA NADI WHICH ON ABSORBSION OF SUNLIGHT PRODUCES BIODEGRADABLE NANO GOLD COLLOIDS IN URINE
http://ajitvadakayil.blogspot.com/2013/02/gomutra-drinking-cows-urine-as-elexir.html
http://ajitvadakayil.blogspot.com/2020/05/warnings-issued-to-amul-milk-marketing.html
VADAKAYIL FORESEES A “VACCINOSIS “ RELATED INCREASE IN VARIANT CREUTZFELDT-JACOB DISEASE (VCJD), A PRION DISEASE (OR PROTEIN MISFOLDING DISEASE) COMPARABLE TO MAD COW DISEASE.
PRION PROTEINS CAN SEED OTHER UNRELATED PROTEINS TO MISFOLD. THERE IS A LIST OF PROTEINS THAT WILL “CATCH THE DISEASE” WHEN THERE IS A PRION OR PRION-LIKE PROTEIN NEAR THEM, THAT MISFOLDS IN A CHARACTERISTIC WAY CALLED “BETA-SHEETS.”
PROTEIN FOLDING IS ESSENTIAL FOR LIFE, AS PROTEINS SERVE STRUCTURAL ROLES, CATALYZE ENZYMATIC REACTIONS, AND TRANSPORT MATERIALS THROUGH MEMBRANES AND CELLS, AMONG MANY OTHER FUNCTIONS..
TDP-43 OR FUS-INDUCED MISFOLDED HUMAN WILD-TYPE SOD1 CAN PROPAGATE INTERCELLULARLY IN A PRION-LIKE FASHION..
MISFOLDED HUMAN WILD-TYPE (HUWT) SOD1 HAS BEEN DETECTED IN BOTH FAMILIAL AND SPORADIC ALS PATIENTS.
PRIONS ARE INFECTIOUS PROTEINS THAT CAN CONVERT TO AN ALTERNATIVE CONFORMATION . THIS ALTERNATIVE CONFORMATION TYPICALLY HARBORS A REGION THAT ADOPTS THE AMYLOID FOLD. AMYLOID IS COMPRISED OF STACKED BETA SHEETS WHICH CAN TEMPLATE THE CONVERSION OF NATIVE PROTEIN TO THE AMYLOID FOLD..
TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES (TSES OR PRION DISEASES) OF INVARIABLY FATAL NEURODEGENERATIVE DISORDERS AFFECT HUMANS AND OTHER MAMMALS. TSES ARE PROTEIN MISFOLDING DISEASES THAT INVOLVE THE ACCUMULATION OF AN ABNORMALLY AGGREGATED FORM OF THE NORMAL HOST PRION PROTEIN (PRP).
IT CAUSES OTHER PROTEINS IN THAT SAME CELL TO MISFOLD IN THAT SAME WAY AND TO BIND TOGETHER IN FIBRILS THAT EVENTUALLY PRECIPITATE OUT. ALZHEIMER’S IS A CLASSIC PRION-LIKE DISEASE. THE AMYLOID BETA PLAQUE IS LINKED TO ALZHEIMER’S.
AMYLOID BETA PLAQUES NORMALLY FOLD AS ALPHA HELICES, THEY ARE LIKE SCREWS THAT GO INTO THE MEMBRANE. ALL PRION PROTEINS HAVE THAT CHARACTERISTIC. THEY NORMALLY GO INTO A MEMBRANE AND FORM AN ALPHA HELIX.
WHEN PRION PROTEINS MISFOLD, AND THEY CAN MISFOLD WHEN YOU GET TOO MANY OF THEM IN THE CYTOPLASM, FOR EXAMPLE IF THERE IS TOO MUCH ALPHA-SYNUCLEIN AMYLOID-BETA, THOSE ALPHA-SYNUCLEIN AMYLOID-BETA MOLECULES START GLOMMING TOGETHER IN THESE BETA SHEETS THAT ARE QUITE SOLUBLE, SO THEY END UP WITH SOLUBLE COMPLEXES OF BETA SHEETS THAT ARE MANY AMYLOID BETAS.
### ALPHA-SYNUCLEIN MISFOLDING GOES WITH PARKINSON’S DISEASE..
### AMYLOID-BETA GOES WITH ALZHEIMER’S..
### TDP43 GOES WITH ALS..
AMYLOID BETA, ALPHA-SYNUCLEIN AND THE SPIKE PROTEIN ARE ALL PRION-LIKE PROTEINS BECAUSE THEY HAVE SIMILAR CHARACTERISTICS. THE CHARACTERISTICS ARE WELL-DEFINED IN TERMS OF THE PROTEIN ITSELF BECAUSE THERE IS A SPECIFIC PATTERN, CALLED A GLYCINE ZIPPER. THE GLYCINE ZIPPER HAS A SIGNIFICANT STRUCTURAL IMPACT, ENGENDERING A STRONG DRIVING FORCE FOR RIGHT-HANDED PACKING AGAINST A NEIGHBORING HELIX.
IT’S A PATTERN OF GXXXG, TWO GLYCINES (AMINO ACID), SEPARATED BY THREE WILD CARDS, IT COULD BE ANY AMINO ACIDS. PROTEINS ARE BUILT FROM AMINO ACIDS LIKE BEADS ON A STRING.
YOU HAVE 20 AMINO ACIDS THAT MAKE UP THE CORE OF ALL THE PROTEINS. YOU HAVE THE DNA CODE THAT INSTRUCTS HOW THE PROTEIN IS MADE. THIS GXXXG PATTERN IS A CHARACTERISTIC PRION PATTERN CALLED A GLYCINE ZIPPER.
AMYLOID BETA HAS FOUR GLYCINE ZIPPERS. AND THE SPIKE PROTEIN HAS FIVE. SO IT’S IN SOME
PRION-LIKE PROTEINS CAUSE DISEASES BY INDUCING CERTAIN NORMAL PROTEINS TO FOLD INCORRECTLY. THERE IS A LIST OF PROTEINS NORMALLY FOUND IN THE BODY THAT ARE SUSCEPTIBLE TO MISFOLDING IN THE PRESENCE OF THESE PRION-LIKE PROTEINS.
CREUTZFELDT-JACOB DISEASE (CJD), THE HUMAN EQUIVALENT OF MAD COW DISEASE, IS ALSO A PRION DISEASE. WHEN MISFOLDED PROTEINS BECOME TOO ABUNDANT IN THE CELL’S CYTOPLASM, THEY CAN START PACKING TOGETHER IN SOLUBLE FIBRILS OR PLAQUES, SUCH AS THE AMYLOID BETA SHEETS IN ALZHEIMER’S, AND CREATE TISSUE DAMAGE.
IN PARKINSON’S DISEASE, AN AMYLOID PROTEIN (CALLED CURLI) PRODUCED BY E. COLI IN THE GUT, IS TRANSPORTED BY IMMUNE CELLS TO THE SPLEEN.
IN THE SPLEEN’S GERMINAL CENTRES (GERMINAL CENTRES ARE AREAS IN LYMPHOID TISSUE WHERE MATURE B CELLS, WHICH PRODUCE ANTIBODIES, PROLIFERATE, DIFFERENTIATE, AND MUTATE), THE IMMUNE CELLS PACK UP THE PRION PROTEIN INTO LITTLE PARTICLES THAT THEY RELEASE AS EXOSOMES, WHICH ARE MEMBRANE-BOUND EXTRACELLULAR VESICLES.
THE CELL IS TRYING TO GET RID OF THESE DANGEROUS, MISFOLDED PROTEINS BY EXPORTING THEM IN EXOSOMES. THESE EXOSOMES GET TRANSPORTED BY THE VAGUS NERVE TO THE BRAIN STEM AND CAN ALSO END UP BEING COUGHED OUT, OR SHED IN THE SWEAT, AND EVEN POSSIBLY GET INTO BREAST MILK.
THERE IS A SPECIFIC PATTERN, CALLED THE GLYCINE ZIPPER, THAT IS CHARACTERISTIC OF PRION-LIKE PROTEINS. IT CONSISTS OF TWO GLYCINES (GLYCINE IS AN AMINO ACID) SEPARATED BY ANY OTHER THREE OTHER AMINO ACIDS (GXXXG). AGAIN, AMYLOID BETA, WHICH CAUSES ALZHEIMER’S, HAS FOUR GLYCINE ZIPPERS. THE SPIKE PROTEIN HAS FIVE.
PARKINSON’S IS AN EXAMPLE. YOU CAN START WITH A PROTEIN PRODUCED BY E. COLI THAT IS A PRION-LIKE PROTEIN. IF IT GETS TOO MUCH, IT STARTS TO MISFOLD, IT STARTS TO BUILD THE PRION C IN THE GUT. AND THEN THE IMMUNE CELLS PICK UP THAT PROTEIN, TRANSPORT IT INTO THE SPLEEN.
THERE ARE GERMINAL CENTRES IN THE SPLEEN WHERE THE PRION PROTEINS REALLY GET GOING. SPLEEN IS A KIND OF A SPECIAL FACTORY FOR TRYING TO DEAL WITH PRION PROTEINS TO GET RID OF THEM. IN THE GERMINAL CENTRES IN THE SPLEEN, THE IMMUNE CELLS PACK UP PRION PROTEINS INTO LITTLE PARTICLES THAT THEY RELEASE AS EXOSOMES.
SPLEEN FIGHTS INVADING GERMS IN THE BLOOD (THE SPLEEN CONTAINS INFECTION-FIGHTING WHITE BLOOD CELLS) IT CONTROLS THE LEVEL OF BLOOD CELLS (WHITE BLOOD CELLS, RED BLOOD CELLS AND PLATELETS) IT FILTERS THE BLOOD AND REMOVES ANY OLD OR DAMAGED RED BLOOD CELLS.
THE SPLEEN IS THE LARGEST LYMPHATIC ORGAN IN THE BODY. THE SPLEEN PLAYS AN IMPORTANT ROLE IN THE IMMUNE SYSTEM.
MRNA VACCINES RE-ENGINEER THE PROTEIN TO MAKE IT MORE PRION-LIKE THAN IT NORMALLY IS. BECAUSE THEY HAVE MUCKED WITH THE PROTEIN STRUCTURE TO GIVE IT A PAIR OF PROLINES THAT ARE NEXT DOOR TO EACH OTHER.
THEY’VE MODIFIED THE SPIKE PROTEIN DESIGN FOR THE VACCINE SUCH THAT IT COULDN’T GO INTO THE MEMBRANE THE PROTEIN IS MADE BY THESE CELLS UNDER INSTRUCTION FROM THE VACCINE, AND THEN IT’S RELEASED AND EXPOSED ON THEIR MEMBRANE.
THE IMMUNE CELLS PICK UP THE VACCINES, THEY OPEN UP THAT DON’T UNDERSTAND WHAT’S GOING ON HERE. THEY’VE NEVER SEEN ANYTHING LIKE THIS BEFORE EVERYTHING IS NOT NATURAL IN THESE VACCINES. SO THE IMMUNE CELLS GET REALLY WORRIED AND THEY GO INTO THE LYMPH SYSTEM.
LOTS OF WOMEN ARE GETTING SWOLLEN LYMPH NODES UNDER THEIR ARM WHICH IS A CHARACTERISTIC FEATURE OF BREAST CANCER. FROM THE LYMPH NODES, IT GETS INTO THE LYMPH SYSTEM AND IT WORKS ITS WAY TO THE SPLEEN.
INTRAMUSCULAR CORONAVIRUS 2019 (COVID-19) VACCINATIONS COULD INDUCE IPSILATERAL AXILLARY LYMPH NODE REACTIVITY
IPSILATERAL AXILLARY NODAL REACTIVITY IS COMMONLY SEEN AFTER THE INTRAMUSCULAR ADMINISTRATION OF THE COVID-19 MRNA VACCINES,
THE ENLARGED LYMPH NODES ARE BIG ENOUGH TO BE VISIBLE ON IMAGING SCANS, SUCH AS MAMMOGRAMS, CT SCANS, MRIS, AND ULTRASOUNDS.
http://ajitvadakayil.blogspot.com/2015/10/mammography-induced-breast-cancer-evil.html
AND WHEN YOU GET TOO MUCH OF A PRION PROTEIN IN THE CYTOPLASM, THAT’S WHEN YOU GET IN TROUBLE WITH OTHER PROTEINS MISFOLDING. AND THESE IMMUNE CELLS ACTUALLY UPREGULATE ALPHA-SYNUCLEIN IN RESPONSE TO STRESS. SO THEY’VE GOT TREMENDOUS STRESS IN THOSE DENDRITIC CELLS IN THOSE GERMINAL CENTRES IN THE SPLEEN.
SPIKE PROTEIN IS A PRION-LIKE PROTEIN.
THERE IS AN OLD SAYING IN MEDICINE THAT “THE CURE MAY BE WORSE THAN THE DISEASE.” THE PHRASE CAN BE APPLIED TO MRNA VACCINES.
VACCINE CREATED PRIONS ARE BEING USED AS BIOWEAPONS..
TDP-43 AND FUS ARE NUCLEAR PROTEINS WITH MULTIPLE FUNCTIONS IN MRNA PROCESSING. THEY PLAY KEY ROLES IN ALS (AMYOTROPHIC LATERAL SCLEROSIS) AND FTD (FRONTOTEMPORAL DEMENTIA), WHERE THEY ARE PARTIALLY LOST FROM THE NUCLEUS AND AGGREGATE IN THE CYTOPLASM OF NEURONS AND GLIAL CELLS.
FUNCTIONS OF TDP-43. TDP-43 PERFORMS SEVERAL MRNA-RELATED PROCESSES IN THE NUCLEUS, SUCH AS TRANSCRIPTION, SPLICING, MAINTAINING RNA STABILITY AS WELL AS MIRNA AND LNCRNA PROCESSING. IT IS PREDOMINANTLY A NUCLEAR PROTEIN BUT ALSO SHUTTLES BETWEEN THE NUCLEUS AND THE CYTOPLASM
THE STRIKING FUNCTIONAL AND STRUCTURAL SIMILARITIES OF TDP-43 AND FUS, WHICH ARE BOTH DNA/RNA BINDING PROTEINS, IMPLY THAT ABNORMAL RNA METABOLISM IS A PIVOTAL EVENT,
FUS (FUS RNA BINDING PROTEIN) IS A PROTEIN CODING GENE. DISEASES ASSOCIATED WITH FUS INCLUDE AMYOTROPHIC LATERAL SCLEROSIS.. FUS IS UBIQUITOUSLY EXPRESSED IN ALL CELLS.
THE FUS PROTEIN ATTACHES (BINDS) TO DNA AND REGULATES AN ACTIVITY CALLED TRANSCRIPTION, WHICH IS THE FIRST STEP IN THE PRODUCTION OF PROTEINS FROM GENES. THE FUS PROTEIN IS ALSO INVOLVED IN PROCESSING MOLECULES CALLED MESSENGER RNA (MRNA), WHICH SERVE AS THE GENETIC BLUEPRINTS FOR MAKING PROTEINS.
THESE BINDING PROTEINS HAVE AMINO ACID REGIONS, BINDING MOTIFS THAT BIND SPECIFIC RNA SEQUENCES. BINDING TO CERTAIN RNA SEQUENCES WHEN THE PROTEINS ARE IN THE CYTOPLASM IS THE REASON WHY MOLECULES TO FOLD IN CERTAIN WAYS LEADING TO PATHOLOGIC AGGREGATION AND PRION FORMATION IN THE CYTOPLASM
COVID-19 VACCINE CONTAINS RNA SEQUENCES THAT HAVE BEEN SHOWN TO HAVE HIGH AFFINITY FOR TDP-43 OR FUS THAT INDUCE CHRONIC DEGENERATIVE NEUROLOGICAL DISEASES.
THE VIRAL SPIKE PROTEIN, CODED BY THE VACCINE RNA SEQUENCE, BINDS ACE2 AN ENZYME CONTAINING ZINC MOLECULES THIS INTERACTION INCREASES INTRACELLULAR ZINC LEVELS LEADING TO PRION DISEASE
THE INITIAL BINDING IS BETWEEN SPIKE PROTEINS ON THE SURFACE OF THE CELL TRANSFECTED BY THE MRNA VACCINE AND ACE2 ON THE SURFACE OF AN ADJACENT CELL.
THE INTERACTION COULD INITIALLY TAKE PLACE IN THE CYTOPLASM OF A CELL THAT MAKES ACE2 AND HAS BEEN TRANSFECTED WITH THE VACCINE RNA CODING FOR THE SPIKE PROTEIN.
THE INTERACTION IS QUITE CONCERNING GIVEN THE SUSPICION THAT THE WUHAN VIRUS CAUSING COVID-19, SARS-COV-2, IS A BIOWEAPON AND IT IS POSSIBLE THAT THE VIRAL SPIKE PROTEIN MAY HAVE BEEN DESIGNED TO CAUSE PRION DISEASE
PFIZER VACCINE USES A UNIQUE RNA NUCLEOSIDE 1-METHYL-3′-PSEUDOURIDYLYL -- THIS NUCLEOSIDE WAS CHOSEN TO REDUCE ACTIVATION OF THE INNATE IMMUNE SYSTEM
RNA MOLECULES CONTAINING THIS NUCLEOSIDE WILL UNDOUBTEDLY HAVE ALTERED BINDING
THE USE OF THIS NUCLEOSIDE IN A VACCINE CAN POTENTIALLY ENHANCE THE BINDING AFFINITY OF RNA SEQUENCES CAPABLE OF CAUSING TDP-43 AND FUS TO ASSUME TOXIC CONFIGURATIONS. THE VACCINE PLACES A NOVEL MOLECULE, SPIKE PROTEIN, IN/ON THE SURFACE OF HOST CELLS.
THE NORMAL PROGRESSION OF PARKINSON’S DISEASE SHOW HOW HOW THE SPIKE PROTEIN ACTS AS A DISEASE-PRODUCING PRION.
PD IS A PRION DISORDER RESULTING FROM INCREASED PRODUCTION AND/OR IMPAIRED CLEARANCE OF PROTEINS SUCH AS Α-SYNUCLEIN, LEADING TO MISFOLDING AND THE FORMATION OF TOXIC OLIGOMERS, AGGREGATES, AND CELL DEATH.
MODERNA AND PFIZER-BIONTECH’S “PSEUDO-VACCINES” FOR COVID-19 CONTAIN MRNA
ENVELOPED BY LIPID NANOPARTICLES (LNP) AND POLYETHYLENE GLYCOL (PEG). NONE OF THESE 3 COMPONENTS HAVE BEEN APPROVED FOR VACCINES MODERNA AND PFIZERBIONTECH USE LNPS THAT ARE “PEGYLATED”, THAT IS, CHEMICALLY BOUND TO PEG MOLECULES TO INCREASE STABILITY AND PREVENT THEIR METABOLISM
THIS EXPERIMENTAL IGT THERAPY AND ITS LNP + PEG-BASED DELIVERY SYSTEM HAVE NEVER BEEN APPROVED FOR USE IN A VACCINE OR DRUG4. EVEN THESE 2 VACCINES WERE ONLY “AUTHORIZED FOR EMERGENCY
USE” BY THE FDA OF THE UNITED STATES, BUT “IT HAS NOT BEEN APPROVED FOR ROUTINE CLINICAL USE”.. “GENE THERAPIES AND DRUGS BASED ON MRNA CAN ACTIVATE ONE OR MORE IMMUNE RESPONSES AGAINST EACH AND EVERY ONE OF THE DRUG’S COMPONENTS ... LEADING TO TERRIBLE ADVERSE EVENTS RELATED TO THE IMMUNE REACTION
THE IMMUNE CELLS KEEP MAKING THE SPIKE PROTEIN BECAUSE THE RNA IN THE VACCINE HAS BEEN ENGINEERED TO BE VERY STURDY. NORMAL RNA WOULD JUST DISINTEGRATE IF YOU INJECTED IT INTO THE BODY. BUT THEY HAVE ADDED POLYETHYLENE GLYCOL AND CHANGED ONE OF THE NUCLEOTIDES IN THE VACCINE RNA, AMONG OTHER THINGS, TO KEEP IT FROM BREAKING DOWN.
THIS MEANS THAT CELLS CAN’T STOP THEMSELVES FROM MAKING THE SPIKE PROTEIN. IT IS WHEN YOU HAVE TOO MUCH OF A PRION PROTEIN IN THE CYTOPLASM THAT YOU ARE IN DANGER OF HAVING MISFOLDING.
T RETROVIRUSES INTRODUCE THEIR GENETIC MATERIAL PERMANENTLY INTO OUR DNA. IN FACT, 8% OF OUR GENETIC CODE IS OF VIRAL ORIGIN, KNOWN AS “RETROVIRAL GENES”
UNTIL NOW, MRNA VACCINES HAD NEVER BEEN USED CLINICALLY WE DON’T KNOW – THOUGH PFIZER / MODERNA COMPANIES THAT MANUFACTURE MRNA VACCINES, FIRMLY ASSURE THAT SAID GENETIC MATERIAL CANNOT BE INTRODUCED INTO OUR GENOME.
APPIDIYAA? AIYOOOOOO ! TOBAH TOAHBAAAHHH ..
I WILL DWELL BRIEFLY FOR THE LCD..
THEY ARE BASED ON THE CONCEPT OF UNIDIRECTIONALITY OF THE FLOW OF CELLULAR GENETIC INFORMATION TO AFFIRM THAT THERE IS NO POSSIBILITY OF MUTAGENESIS OF OUR DNA BY INSERTION OF MRNA SINCE IT IS LITERALLY IMPOSSIBLE FOR IT TO ENTER THE CELL NUCLEUS. WITH PFIZER HAVING JAWS 1/ JAWS 2 / JAWS 3 BOOSTER JABS THERE IS 99.9%
LIKEHOOD THAT SAID GENETIC MATERIAL WILL END UP FORMING PART OF OUR CHROMOSOMES. DURING CELL DIVISION (MITOSIS AND MEIOSIS), THERE ARE PHASES IN WHICH THE NUCLEAR MEMBRANE DISAPPEARS, AND THE CHROMOSOMES MIX WITH THE CYTOPLASM. AFTER THESE PHASES, THE NUCLEAR MEMBRANE IS REBUILT,
AND IT IS EMINENTLY POSSIBLE FOR MRNA FROM VACCINES TO BE INCLUDED INSIDE THE NEW NUCLEUS . AFTER CELL DIVISIONS, A NEW NUCLEAR MEMBRANE IS RECREATED, AND THE CHROMOSOMES REVERT TO A NONCOMPACTED CONFORMATIONAL SITUATION.
THIS DECONDENSATION OF THE CHROMOSOMES GIVES RISE TO CHROMATIN, WHICH REPRESENTS A FULLY FUNCTIONAL STATE OF OUR DNA. UNDER THESE CONDITIONS, THE INTRODUCTION OF THE VACCINE MRNA INTO OUR GENETIC MATERIAL IS ONLY A MATTER OF TIME MITOSIS: IT IS THE PROCESS OF CELL DIVISION WHOSE RESULT IS THE FORMATION OF TWO DAUGHTER CELLS WITH THE SAME NUMBER OF CHROMOSOMES.
IT DEVELOPS OVER FIVE PHASES: PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, AND TELOPHASE. DURING PROMETAPHASE, THERE IS A FRAGMENTATION OF THE NUCLEAR MEMBRANE IN MULTIPLE VESICLES. NEXT, THE MITOTIC SPINDLE IS FORMED.
IT IS A SET OF MICROTUBULES THAT ARISE FROM THE CENTRIOLES DURING THE PROCESSES OF CELL DIVISION (WHETHER MITOSIS OR MEIOSIS) AND THAT GO FROM THE CENTROMERES OF THE CHROMOSOMES TO THE CENTRIOLES LOCATED AT THE POLES.
IT IS IMPORTANT TO UNDERSTAND THAT SINCE THE CENTRIOLES ARE LOCATED OUTSIDE THE NUCLEUS, THE MICROTUBULES OF THE SPINDLE CANNOT ATTACH TO THE CENTROMERES OF THE CHROMOSOMES UNTIL THE NUCLEAR MEMBRANE IS BROKEN. ONCE THE MITOTIC SPINDLE IS CREATED, THE SISTER CHROMATIDS ARE PULLED IN OPPOSITE DIRECTIONS TOWARDS BOTH POLES OF THE SAME AND WILL GIVE RISE TO THE FUTURE DAUGHTER CHROMOSOMES.
DURING TELOPHASE, THE DAUGHTER CHROMOSOMES ELONGATE, LOSE CONDENSATION AND THE NUCLEAR MEMBRANE IS RECOVERED, WHICH IS FORMED AGAIN FROM THE ROUGH ENDOPLASMIC RETICULUM
DURING MITOSIS THERE IS A TOTAL REORGANIZATION OF THE CELLULAR MATERIAL DURING WHICH, THE MOLECULES PRESENTED IN THE CELL CYTOPLASM (PROTEINS, LIPIDS, MRNA) CAN END UP BEING INCLUDED DURING TELOPHASE WITHIN THE NEW CELL NUCLEUS AND LATER JOIN OUR DNA THROUGH AN RT.
MITOSIS INVOLVES THE DIVISION OF BODY CELLS, WHILE MEIOSIS INVOLVES THE DIVISION OF SEX CELLS. THE DIVISION OF A CELL OCCURS ONCE IN MITOSIS BUT TWICE IN MEIOSIS.
MEIOSIS IS THE PROCESS OF CELL DIVISION, TYPICAL OF EUKARYOTIC REPRODUCTIVE CELLS, IN WHICH THE NUMBER OF CHROMOSOMES IS REDUCED BY HALF TO CREATE HAPLOID SEX CELLS OR GAMETES (EGGS AND SPERM) THAT CONTAIN A SINGLE COPY OF EACH CHROMOSOME WHICH, WHEN THEY UNITE, WILL FORM A ZYGOTE WITH THE COMPLETE NUMBER OF CHROMOSOMES.
THE MEIOSIS PROCESS TAKES THE FORM OF DNA REPLICATION FOLLOWED BY TWO SUCCESSIVE NUCLEAR AND CELLULAR DIVISIONS. THESE DIVISIONS OR PHASES ARE CALLED MEIOSIS I AND MEIOSIS II . AS IN MITOSIS,
MEIOSIS I IS PRECEDED BY INTERPHASE, A PROCESS OF DNA REPLICATION THAT TURNS EACH CHROMOSOME INTO TWO SISTER CHROMATIDS. MEIOSIS I IS A SPECIAL CELL DIVISION IN WHICH HOMOLOGOUS PAIRS OF CHROMOSOMES ARE SEPARATED AND THEIR GENETIC MATERIAL IS REDUCED FROM A DIPLOID CELL TO A HAPLOID CELL.
A SECOND PHASE OF GROWTH CALLED INTERKINESIS CAN OCCUR BETWEEN MEIOSIS I AND II, HOWEVER, DNA REPLICATION DOES NOT OCCUR AT THIS STAGE .
THE EVENTS OF MEIOSIS II ARE ANALOGOUS TO THOSE OF A MITOTIC DIVISION, ALTHOUGH THE NUMBER OF CHROMOSOMES INVOLVED HAS BEEN REDUCED BY HALF. MEIOSIS IS A BASIC PROCESS TO GENERATE A GREATER GENETIC DIVERSITY IN OFFSPRING SINCE THE GAMETES OF BOTH PARENTS WILL CONTRIBUTE HALF OF THE GENETIC LOAD TO THE CREATED ZYGOTE ..
AS IN THE PROMETAPHASE OF MITOSIS, DURING THE PROMETAPHASE OF MEIOSIS I AND II, A FRAGMENTATION OF THE NUCLEAR MEMBRANE OCCURS IN MULTIPLE VESICLES. IN THE SAME WAY, DURING BOTH PHASES OF MEIOSIS, A TOTAL REORGANIZATION OF THE CELLULAR MATERIAL OCCURS DURING WHICH,
THE MOLECULES PRESENT IN THE CELL CYTOPLASM (PROTEINS, LIPIDS, MRNA) CAN END UP WRAPPED WITHIN THE NEW CELL NUCLEUS AND THEREFORE JOIN TO OUR DNA IN THE SAME WAY AS IN MITOSIS . HOWEVER, IN THIS CASE, THE CONSEQUENCES MAY BE MORE SERIOUS BECAUSE SAID GENETIC MUTATION WOULD BE TRANSMITTED TO OUR OFFSPRING
THE BINDING OF GENETIC MATERIAL TO LIPID COATINGS SIGNIFICANTLY IMPROVES PENETRATION INTO THE NUCLEUS.
THESE COATINGS PROMOTE NUCLEAR ENTRY THROUGH FUSION WITH THE NUCLEAR ENVELOPE (LIPOPLEXES) OR PERMEATION OF THE NUCLEAR MEMBRANE (POLYPLEXES)., BY MEANS OF POLYMERASE CHAIN REACTION AND ELECTRON MICROSCOPY ANALYSIS, IT WAS DISCOVERED THAT WHEN WE INTRODUCE PLASMIDS, PROTECTED BY LIPOPLEXES AND POLLEXES, INTO THE CYTOPLASM, BETWEEN 1 AND 10% MANAGE TO PENETRATE THE NUCLEO
THE ELECTRICAL CHARGES OF THESE MOLECULES AND THE MEMBRANE COULD BE AN EXPLANATION FOR THIS PROCESS THE BINDING OF THE IMPORTIN COMPLEX TO AN NLS INCREASES ITS BINDING TO DNA, DILATES THE NUCLEAR PORES AND INCREASES THE TRANSLOCATION OF GENETIC MATERIAL FROM THE CYTOPLASM TO THE NUCLEUS..
BELOW: AT 1.53-- DR ANTHONY FAUCI, COME FOR A LIVE DEBATE WITH VADAKAYIL.. BRING A BUCKET OF GREASE ALONG.. I WILL RAPE YOUR EGO.
PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA IS JUST A PIMP OF THE JWISH VACCINE LOBBY WHO BRIBES / HONEY TRAPS US CONGRESSMEN/ SENATORS/ JUDGES/ FBI/ CIA/ POLICE/ MEDIA/ FAKE OPINION POLL CONDUCTORS/ HASBARAS/ HEALTH CARE MOVERS AND SHAKERS/ STATISTICS HOUSES...
THE PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PHRMA), PUBLICLY ENDORSED PORTIONS OF THE PATIENT PROTECTION AND AFFORDABLE CARE ACT, AS DID SEVERAL OTHER MAJOR PHARMACEUTICAL MANUFACTURERS. THIS ORG IS A DEMOCRAT PARTY WING.
WHEN MAIN STREAM MEDIA REPORTS LOBBYING EXPENSE – MULTIPLY BY FOUR AS A THUMBRULE.
https://www.reuters.com/world/us/pfizer-unions-others-donated-618-mln-bidens-inaugural-2021-04-21/
HUNDREDS OF MILLIONS OF US DOLLARS ARE SPENT IN LOBBYING ( PIMPING )..MORE MONEY IS SPENT IN BRIBING THAN FOR ACTUAL MEDICAL RESEARCH SOMETIMES.
IN 2020 MORE THAN 600 MILLION USD FOR SPENT BY KOSHER BIG PHARMA FOR LOBBYING. A LOT OF THIS MONEY CAME TO MODI ..
THE ABILITY TO LOBBY — TO PETITION THE GOVERNMENT FOR REDRESS — IS PROTECTED BY THE FIRST AMENDMENT OF THE CONSTITUTION. LOBBYISTS DONATE MONEY TO CANDIDATES. THIS IS PERFECTLY LEGAL!!!
SOME INTEREST GROUPS WILL SEND MEMBERS OF CONGRESS AND THEIR STAFFS ON TRIPS, SOMETIMES TO PEDOPHILE ISLAND OF JEW JEFFREY EPSTEIN.
https://www.latimes.com/opinion/story/2021-07-18/opioid-crisis-oxycontin-purdue-pharma-sackler-settlement
MILLIONS OF COVID PATIENTS HAVE DIED DUE TO LIVER DAMAGE BY PARACETAMOL..
PFIZER INC IS BULLYING LATIN AMERICAN NATIONS TO CHANGE THEIR LAWS TO PROVIDE PROTECTION FOR ITS HIGH-PRICED VACCINE. REMEMBER THAT PFIZER’S PARTNER BIONTECH GOT $445 MILLION FROM JEWESS ANGELA MERKEL ( WITH HILTER’S EYES AND CHIN WHO CAN NEVER WIN AN ELECTION UNLESS IT IS RIGGED ) THE GERMAN GOVERNMENT TO DEVELOP THIS VACCINE..
JEW BARACK OBAMA ( HIS MOTHER IS A WHITE JEWESS ) WAS A PENNILESS BUM DURING AFTER HIS COLLEGE DAYS..
https://www.mansionglobal.com/articles/barack-and-michelle-obama-reportedly-close-deal-for-11-75-million-marthas-vineyard-estate-209977?reflink=outbrain_editorial-int_%24section_id%24&reflink=outbrain_editorial-int_0070127ff51beae958a5d2ecf3ed736607&dicbo=v1-0392d0490587150f7e51ea650c8d809c-00f0464d4134b070538283435e8e7fd395-gbrdcobwgaztallbguydcljumrsdoljymfsggllbga3tcodfmy4toobvmu
JEWISH PFIZER IS A CRIMINAL COMPANY.. WORSE THAN PURDUE
https://www.globalresearch.ca/video-pfizers-criminal-record-largest-medical-fraudulent-marketing-case-in-us-history/5745183
https://www.cpmlegal.com/blogs-Advocates-For-Justice/what-are-the-top-pharmaceutical-litigation-settlements
PFIZER PAID KICKBACKS TO HEALTH CARE PROVIDERS TO INDUCE THEM TO PRESCRIBE THESE, AS WELL AS OTHER, DRUGS.
SIX WHISTLE BLOWERS RECEIVED PAYMENTS TOTALING MORE THAN $102 MILLION FROM THE FEDERAL SHARE OF THE CIVIL RECOVERY.
WE HAVE ICMR IN INDIA-- WE TAX PAYERS SUPPORT THIS USELESS ORG WHO DOES NOTHING OTHER THAN DANCE TO THE TUNE OF THE KOSHER PHARMA VACCINE LOBBY..
ICMR KEEPS DUMBOS IN THEIR PAYROLL , JUST DO NOTHING. JUST FOLLOW ORDERS OF THEIR JEWISH MASTERS. AND NOW MODI HAS A NEW GUJARATI HEALTH MINISTER WHO DOES NOT KNOW ENGLISH.
https://en.wikipedia.org/wiki/Indian_Council_of_Medical_Research
THIS IS LIKE INDIAN ICE STATION HIMADRI IN THE ARCTIC.. THEY DO NOTHING.. THEY JUST DANCE TO THE TUNE OF THE JEWS WHO SAY THAT CO2 AND INDIAN COAL CAUSES CLIMATE CHANGE.
https://en.wikipedia.org/wiki/Himadri_(research_station)
MESSAGE FROM CAPT AJIT VADAKAYIL TO PM JAMES MARAPE OF PAPUA NEW GUINEA
THE WHITE MAN IS ACCUSING NATIVES OF PAPUA NEW GUINEA OF DOING RITUALISTIC / VIA FUNERARY CANNIBALISM CAUSING PRION KURU DISEASE.. A DEADLY INCURABLE AND FATAL NEURODEGENERATIVE DISORDER..
THE TERRIFIC LIE IN WIKIEPDIA IS QUOTE: THE EPIDEMIC LIKELY STARTED WHEN A VILLAGER DEVELOPED SPORADIC CREUTZFELDT–JAKOB DISEASE AND DIED. WHEN VILLAGERS ATE THE BRAIN, THEY CONTRACTED THE DISEASE, AND IT WAS THEN SPREAD TO OTHER VILLAGERS WHO ATE THEIR INFECTED BRAINS : UNQUOTE
https://en.wikipedia.org/wiki/Kuru_(disease)
PEOPLE OF PAPUA NEW GUINEA WERE NOT CANNIBALS.
I WAS SHIP CAPTAIN OF MT NORTH CONTENDER PLYING BETWEEN ALL PORTS OF PAPUA NEW GUINEA –TWO CONTRACTS—MEANING 1O MONTHS.. PORT MORESBY/ KIMBE/ LAE/ RABAUL/ MADANG / WEWAK/ KAVIENG.. I SET UP THE SYSTEMS THERE ( SHELL CHARTER )
MY STAINLESS STEEL CHEMICAL TANKER BROUGHT GASOLINE / JET FUEL / HIGH SPEED DIESEL , TO PAPUA NEW GUINEA.
http://ajitvadakayil.blogspot.com/2010/12/annex1-oil-products-on-stainless-steel.html
JAPANESE ATE 21,000 INDIAN SOLDIERS ON RABAUL ISLAND DURING WW2.. WHAT THEY COULD NOT EAT THEY THREW AWAY AND THE STARVING LOCALS SCROUNGED AND ATE THEM ..
THE JAPANESE WERE CAREFUL NOT TO EAT HUMAN BODY PARTS LIKE BRAIN/ LIVER WHICH WILL GIVE THEM PRION DISEASE..
WITH CONTINUOUS BOMBING ON THE ISLAND THE FLORA AND FAUNA WERE DECIMATED AND POLLUTED.. AND THE HIGHLANDER LOCALS WERE NOT GOOD IN FISHING.
https://ajitvadakayil.blogspot.com/2011/08/netaji-subhash-chandra-bose-untold.html
FROM NOW ON , FIRMLY STOP ALLEGATIONS THAT PAPUA NEW GUINEA INFECTED THE PLANET WITH PRION DISEASES..
https://ajitvadakayil.blogspot.com/2021/07/welcome-to-real-dystopian-world-of.html
NOW MRNA VACCINES ARE CAUSING PRION DISEASES .. THE BLAME WILL AGAIN COME ON PAPUA NEW GUINEA.
https://captajitvadakayil.in/2021/07/24/vadakayil-declares-that-mrna-vaccines-cause-prion-diseases-poll/
capt ajit vadakayil
..
SLEEP DISORDERS ARE A HALLMARK SYMPTOM OF A GENETICALLY TRANSMITTED PRION DISEASE CALLED FATAL FAMILIAL INSOMNIA.
FATAL LEADS TO DETERIORATION OF MENTAL FUNCTION AND LOSS OF COORDINATION. DEATH OCCURS WITHIN A FEW MONTHS TO A FEW YEARS.
FFI IS CAUSED BY A MUTATION OF THE PRNP GENE. THIS MUTATION CAUSES AN ATTACK ON THE THALAMUS, WHICH CONTROLS YOUR SLEEP CYCLES AND ALLOWS DIFFERENT PARTS OF YOUR BRAIN TO COMMUNICATE WITH EACH OTHER. IT'S CONSIDERED A PROGRESSIVE NEURODEGENERATIVE DISEASE.
MORE THAN 30 MUTATIONS IN THE PRNP GENE HAVE BEEN IDENTIFIED IN PEOPLE WITH FAMILIAL FORMS OF PRION DISEASE, INCLUDING CREUTZFELDT-JAKOB DISEASE (CJD), GERSTMANN-STRÄUSSLER-SCHEINKER SYNDROME (GSS), AND FATAL FAMILIAL INSOMNIA (FFI).
PRNP GENE MUTATIONS RESULT IN THE PRODUCTION OF AN ABNORMALLY SHAPED PROTEIN , KNOWN AS PRPSC, FROM ONE COPY OF THE GENE.
FFI IS CLASSIFIED AS A TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY (TSE) OR A PRION DISEASE. PRION DISEASES ARE CAUSED BY THE ACCUMULATION OF MISFOLDED PRION PROTEINS IN THE BRAIN. THERE IS NO CURE
THE ABNORMAL FOLDING OF THE PRION PROTEINS LEADS TO BRAIN DAMAGE AND THE CHARACTERISTIC SIGNS AND SYMPTOMS OF THE DISEASE. PRION DISEASES ARE USUALLY RAPIDLY PROGRESSIVE AND ALWAYS FATAL.
PRIONS ARE VIRUS-LIKE ORGANISMS MADE UP OF A PRION PROTEIN. PRIONS ATTACK NERVE CELLS PRODUCING NEURODEGENERATIVE BRAIN DISEASE.
TO CURE A HARMLESS FLU YOU ARE SADDLING THE PLANET WITH VACCINE INDUCED PRION DISEASE ??..
TO CURE A DULL HEAD ACHE FOR AN HOUR TODAY YOU WANT TO INFLICT LIFE LONG MIGRAINE WITH EXCRUCIATING PAIN / VOMITING FOR YOURSELF AND YOUR FUTURE DESCENDANTS ?
IN INDIA PEOPLE RUSHED TO HOSPITALS DURING SECOND WAVE DUE TO FEAR MONGERING BY MAIN STREAM MEDIA.. SHORTNESS OF BREATH COULD BE EASILY MANAGED AT HOME BY NAC..
https://ajitvadakayil.blogspot.com/2021/07/today-on-24th-july-2021-we-in-india.html
98% OF COVID HOSPITAL DEATHS ARE MUD=RDERS BY IGNORANT DOCTORS WHO RECKLESSLY ADMINISTERED PARACETAMOL/ STEROIDS/ DANGEROUS DRUG COBINATIONS AND ENDLESS OXYGEN,
http://ajitvadakayil.blogspot.com/2014/11/sterilisation-deaths-of-13-tribalwomen.html
PRION DISEASES COMPRISE A SINGULAR GROUP OF NEURODEGENERATIVE CONDITIONS CAUSED BY ENDOGENOUS, MISFOLDED PATHOGENIC (PRION) PROTEINS, ASSOCIATED WITH MOLECULAR AGGREGATES. IN HUMANS
CLASSICAL PRION DISEASES INCLUDE CREUTZFELDT–JAKOB DISEASE, FATAL FAMILIAL INSOMNIA, GERSTMANN–STRÄUSSLER–SCHEINKER SYNDROME, AND KURU.
PRION (AFFECTS MAMMALS CAUSING A GROUP OF SLOW, PROGRESSIVE, NEURODEGENERATIVE, LETHAL, UNTREATABLE DISORDERS KNOWN AS TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES (TSES).
OPPOSED TO OTHER CONVENTIONAL PATHOGENS (VIROIDS, VIRUSES, BACTERIA, FUNGI, AND PARASITES) WHICH ARE EXTRINSIC TO THE HOST, THE MISFOLDED PRION PROTEIN HAS AN “ENDOGENOUS ORIGIN”.
THE NATIVELY FOLDED VERSION OF THE PRION PROTEIN, NAMED CELLULAR PRION (PRPC), IS A CELL-SURFACE GLYCOPROTEIN ENCODED BY THE ENDOGENOUS MAMMALIAN GENE PRNP, WHICH IS PRESENT IN ALL VERTEBRATES AND HIGHLY EXPRESSED IN THE BRAIN,
THE PRION PROTEINS (PRP) ARE ENCODED BY THE PRION PROTEIN GENE (PRNP GENE).
PRION DISEASES ARE UNIQUE BY THE FACT THAT (I) THEIR ETIOLOGICAL AGENT IS DEPRIVED OF NUCLEIC ACID .
IN CONTRAST TO VIRUSES OR BACTERIA, UNPRECEDENTEDLY, PRIONS CONSIST OF AMINO ACIDS BUT LACK NUCLEIC ACIDS
PRIONS ARE FORMED WHEN PRP ASSOCIATES WITH A FOREIGN PATHOGENIC NUCLEIC ACID.
PRP PARTICIPATES IN SEVERAL BIOLOGICAL PROCESSES, INCLUDING NEURITOGENESIS, NEURONAL HOMEOSTASIS, CELL SIGNALLING, CELL ADHESION, AND A PROTECTIVE ROLE AGAINST STRESS
PATHOGENIC PRION MULTIPLICATION IS AN EVENT OF STRUCTURAL INFORMATION AMPLIFICATION, RATHER THAN DNA OR RNA REPLICATION.
NEVERTHELESS, SINCE PRPC SYNTHESIS IS DEPENDENT ON TRANSLATION, TRANSCRIPTION, AND ULTIMATELY ON A DNA SEQUENCE, PRPSC REPLICATION IS INDIRECTLY DEPENDENT ON DNA.
PRION DISEASES MAY BE DIAGNOSED BASED ON THE PRESENCE OF PRPSC, FOR EXAMPLE, BY THE PROTEIN MISFOLDING CYCLIC AMPLIFICATION (PMCA)
PRIONS REPRODUCE BY RECRUITING THE NORMAL, CELLULAR ISOFORM OF THE PRION PROTEIN (PRPC) AND STIMULATING ITS CONVERSION INTO THE DISEASE-CAUSING ISOFORM (PRPSC).
HUMAN PRION DISEASES CAUSE PROGRESSIVE LOSS OF MOTOR CONTROL, DEMENTIA (SEVERE LOSS OF MEMORY OR MENTAL FUNCTION), PARALYSIS, AND WASTING (A GREAT LOSS OF BODY AND MUSCLE MASS, .
PRION AGGREGATES CAN CAUSE THE CONVERSION OF PRPC ON ADJACENT CELLS, THUS SPREADING PRPSC AGGREGATES THROUGHOUT THE BRAIN.
PRPC CAN UNDERGO CONVERSION INTO PRPSC THROUGH SPONTANEOUS MISFOLDING, A GENETIC MUTATION OF THE HUMAN PRNP GENE, OR EXPOSURE TO A PRION FROM AN EXTERNAL SOURCE.
PRPC, CELLULAR PRION PROTEIN; PRPSC, SCRAPIE- ASSOCIATED PRION PROTEIN;
PRPC IS ESSENTIAL FOR THE SPREADING OF PRPSC,
PRPC CAN UNDERGO CONVERSION INTO PRPSC THROUGH SPONTANEOUS MISFOLDING, A GENETIC MUTATION OF THE HUMAN PRNP GENE, OR EXPOSURE TO A PRION FROM AN EXTERNAL SOURCE.
PROTEIN MISFOLDING PROCESSES—EXEMPLIFIED BY THE PRION PROTEIN—ARE ALSO MANIFESTED IN HIGHLY PREVALENT NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER’S (AD) AND PARKINSON’S DISEASES (PD), AMONGST 20 HUMAN DISEASES REFERRED TO AS PROTEIN MISFOLDING DISORDERS (PMDS).
PROTEIN MISFOLDING DISORDERS (PMDS) ARE A GROUP OF DISEASES CHARACTERIZED BY THE ACCUMULATION OF ABNORMALLY FOLDED PROTEINS. DESPITE THE WIDE RANGE OF PROTEINS AND TISSUES INVOLVED, PMDS SHARE SIMILAR MOLECULAR AND PATHOGENIC MECHANISMS.
SEVERAL NEURODEGENERATIVE AND OTHER DISEASES RESULT FROM THE ACCUMULATION OF AMYLOID FIBRILS FORMED BY MISFOLDED PROTEINS.
PRIONS, SO-CALLED BECAUSE THEY ARE PROTEINACEOUS, ARE INFECTIOUS PARTICLES, SMALLER THAN VIRUSES, THAT CONTAIN NO NUCLEIC ACIDS (NEITHER DNA NOR RNA).
PRIONS STAND AS THE SINGULAR CLASS OF PATHOGENS DEPRIVED OF NUCLEIC ACIDS, ABLE TO PROMOTE BIOLOGICAL AMPLIFICATION OF STRUCTURAL INFORMATION, AND WHICH DISEASES MAY MANIFEST IN THREE TOTALLY DISTINCT FORMS (INHERITED, SPORADIC OR ACQUIRED).
PRIONS CANNOT BE GROWN IN PURE CULTURE LIKE BACTERIA OR VIRUSES
A MICRORNA (ABBREVIATED MIRNA) IS A SMALL SINGLE-STRANDED NON-CODING RNA MOLECULE (CONTAINING ABOUT 22 NUCLEOTIDES) FOUND IN PLANTS, ANIMALS AND SOME VIRUSES, THAT FUNCTIONS IN RNA SILENCING AND POST-TRANSCRIPTIONAL REGULATION OF GENE EXPRESSION.
BOTH MIRNAS AND PRIONS HAVE BEEN DESCRIBED AS MEDIATORS OF EPIGENETIC INHERITANCE—THE HERITABILITY OF PHENOTYPES IN THE ABSENCE OF CHANGES IN THE NUCLEOTIDE SEQUENCE OF THE CORRESPONDING GENE (
MESSENGER RNA (MRNA) COVID VACCINES CAN TRIGGER DEVELOPMENT OF PRION DISEASES AS WELL AS OTHER CHRONIC AND AUTO IMMUNE DISEASES.
COVID VACCINES ACCELERATING DISEASE PROGRESSION IN INDIVIDUALS WHO EITHER ALREADY HAVE SUBCLINICAL PRION DISEASE OR HAVE MILD PRION DISEASE THAT HAS NOT BEEN PROPERLY DIAGNOSED.
VACCINE SPIKE PROTEIN CAN PROMPT MISFOLDING OF ESSENTIAL RNA/DNA BINDING PROTEINS CALLED TDP-43 AND FUS AND CATALYZE A TOXIC “CHAIN REACTION.”
THE VACCINE SPIKE PROTEIN MAY ALSO CAUSE PROTEINS “INCLUDING [NORMAL] PRIONS ALREADY IN CELLS” TO FORM ABNORMAL CLUMPS (CALLED LEWY BODIES) THAT CAN RESULT IN “RELATIVELY RAPID CELL DEATH.”
LEWY BODY DEMENTIA IS CHARACTERIZED BY THE ABNORMAL BUILDUP OF PROTEINS INTO MASSES KNOWN AS LEWY BODIES. THIS PROTEIN IS ALSO ASSOCIATED WITH PARKINSON'S DISEASE. PEOPLE WHO HAVE LEWY BODIES IN THEIR BRAINS ALSO HAVE THE PLAQUES AND TANGLES ASSOCIATED WITH ALZHEIMER'S DISEASE.
THE SPIKE PROTEIN CAN SO QUICKLY SET ABNORMAL PROTEIN CLUMPING INTO MOTION, THIS “COULD ALLOW FAIRLY RAPID DETECTION OF PRION DISEASE AFTER IMMUNIZATION.”
FLAWED ADVERSE EVENT REPORTING SYSTEMS WILL LIKELY FAIL TO CAPTURE NEURODEGENERATIVE DISEASES THAT TAKE MORE TIME TO DEVELOP. MOST VACCINE ADVERSE EVENT REPORTS ARE FOR ACUTE EVENTS, , WHEREAS FEW OF THE ADVERSE EVENTS THAT OCCUR “YEARS OR DECADES AFTER ADMINISTRATION OF A PHARMACEUTICAL ARE EVER REPORTED.”
PRION DISEASE SYMPTOMS ARE OFTEN NON-SPECIFIC OR OVERLAP WITH OTHER CONDITIONS, MAKING DIAGNOSIS DIFFICULT AND UNDERREPORTING PROBABLE.
THE PFIZER MRNA VACCINE MAY INDUCE MORE TDP-43 AND FUS TO FORM PRIONS AND LEAD TO MORE PRION DISEASE.”
COVID SHOTS ARE FAR FROM THE ONLY VACCINES ADVERSELY AFFECTING THE NERVOUS SYSTEM. S, SYMPTOMS CONSIDERED RED FLAGS FOR NEUROLOGICAL PROBLEMS ABOUND.
THESE SYMPTOMS INCLUDE DIZZINESS, HEADACHES, NUMBNESS, BALANCE DISORDERS, MUSCLE WEAKNESS, PARALYSIS, SEIZURES, VISUAL CHANGES, DISTURBED SLEEP AND TREMORS.
LISTED GUILLAIN-BARRÉ SYNDROME (A DISORDER IN WHICH THE IMMUNE SYSTEM ATTACKS THE NERVES)
GUILLAIN-BARRÉ SYNDROME (GBS) IS A COVID VACCINE ( MOSTLY BY JOHNSONS ) TRIGGERED NEUROLOGICAL DISORDER IN WHICH THE BODY'S IMMUNE SYSTEM MISTAKENLY ATTACKS PART OF ITS PERIPHERAL NERVOUS SYSTEM—THE NETWORK OF NERVES LOCATED OUTSIDE OF THE BRAIN AND SPINAL CORD.
MUSCLE WEAKNESS OR PARALYSIS ARE THE CHARACTERISTIC FEATURES OF GUILLAIN-BARRÉ SYNDROME. THE WEAKNESS OFTEN BEGINS IN THE LEGS AND SPREADS TO THE ARMS, TORSO, AND FACE AND IS COMMONLY ACCOMPANIED BY NUMBNESS, TINGLING, OR PAIN. PEOPLE WITH GUILLAIN-BARRE SYNDROME EXPERIENCE SEVERE NERVE PAIN,
MY SON HAD JOHNSON VACCINE AND HE HAD JET LAG AND BRAIN FOG FOR THREE DAYS
https://www.indiatoday.in/world/story/eu-lists-rare-nerve-disorder-as-side-effect-of-jj-covid19-vaccine-1831413-2021-07-22
SOME INDIVIDUALS RECOVER FROM THE WEAKNESS, TINGLING AND PARALYSIS CHARACTERISTIC OF GUILLAIN-BARRÉ — BUT IN 4% TO 7% OF CASES, THE SYNDROME LEADS TO DEATH.
THUS, WHEN THE FDA ADDED ITS GUILLAIN-BARRÉ WARNING FOR THE J&J COVID-19 VACCINE IN MID-JULY 2021 , THE AGENCY WAS GRUDGINGLY LETTING THE WORLD KNOW SOME COVID VACCINE RECIPIENTS CAN EXPECT SERIOUS OR FATAL NEUROLOGICAL OUTCOMES.
PRION DISEASES – A GROUP OF BRAIN DISEASES CAUSED BY PROTEINS CALLED PRIONS THAT MALFUNCTION AND ‘MISFOLD’, TURNING INTO A FORM THAT CAN ACCUMULATE AND KILL BRAIN CELLS. THESE DISEASES CAN TAKE DECADES TO MANIFEST, BUT ARE THEN AGGRESSIVE AND FATAL.
“PRION DISEASES ARE AGGRESSIVE AND DEVASTATING, AND CURRENTLY THERE IS NO CURE.
.MRNA VACCINES CAUSE THE MUTANT FORM IS MORE AGGRESSIVE, CAUSING PRIONS TO TRANSITION FASTER TO THEIR PATHOGENIC FORM
HOWEVER, PRIONS ARE DIFFICULT TO ISOLATE AND PURIFY FROM OTHER PROTEINS IN SUFFICIENT QUANTITIES TO STUDY IN DETAIL.
SOMEBODY CALLED ME UP AND CRIED
CAPTAIN
YOU WROTE IN THE POST BELOW, THAT WHEN YOU HEARD THAT MARGARET THATCHER WAS FEEDING BRITISH COWS WITH WASTE MEAT..
YOU WROTE THAT YOU SEND A MESSAGE FROM THE SHIP TO MARGARET THATCHER COPIED TO RONALD REAGAN TO STOP IT, STATING THAT COW'S DIGESTIVE SYSTEM CANNOT HANDLE MEAT.
WHY WERE YOU SO MUCH WORRIED?
WELL-
I WARNED MARGARET THATCHER ABOUT BRITISH COWS GOING MAD WITH BRAIN DISEASE.
I WARNED HER HOW KARMA WILL FUCK HER..
I WARNED HER THAT A PRION DISEASE WILL AFFLICT THE WHOLE OF BRITAIN..
I WAS RIGHT.
https://ajitvadakayil.blogspot.com/2021/07/welcome-to-real-dystopian-world-of.html
MARGARET THATCHER DIED OF VARIANT CREUTZFELDT JACOB DISEASE - WHICH THE DOCTORS WHITE WASHED AS ALZHEIMERS..
http://ajitvadakayil.blogspot.com/2013/12/shocking-legacy-of-mad-cow-disease-capt.html
MAGGIE BABY, WAS SO FUCKIN' SMART THAT SHE PRE-RECORDED FUTURE " THANK YOU FOR BIRTHDAY WISHES", " WISH ALL OF YOU MERRY CHRISTMAS "-- FOR FUTURE DATES..
IN THE LAST OF HER WRETCHED LIFE, SHE DID NOT REMEMBER THAT SHE RULED BRITAIN..
I HAD TOLD MARGARET THATCHER THAT PRIONS HAVE VERY LONG INCUBATION PERIOD..
IT IS NOW KICKING IN..
THIS IS WORSE THAN HOMOSEXUALITY..
THE ROLES OF HUSBAND AND WIFE ARE REVERSED..
THE BRITISH WIFE NOW FUCKS HER HUSBAND'S ASSHOLE USING A STRAP ON DILDO.. SHE IS LIKE A ROBOT.. THE MAN CRIED OUT IN PAIN.. SOME ENJOY..
THIS IS BRITAIN'S BEST KEPT SECRET..
CURIOUS FOLKS ( MEN OVER THE AGE OF 18 ONLY )..
GOOGLE FOR "PEGGING SEX UK "..
BE SHOCKED !
KARMA CAN BE A BITCH..
BRITISH SOLDIERS CAME TO INDIA.. JEW ROTHSCHILD ARRANGED GIRLS TO FUCK AFTER FIRST MENSES -- THESE UNFORTUNATE GIRLS WERE MARRIED OFF TO HANUMAN..
ROTHSCHILD CONVERTED A MONKEY TO GOD..
http://ajitvadakayil.blogspot.com/2014/02/devadasi-system-immoral-lie-of-temple.html
THIS WAS FOUL PEDOPHILIA..
HISTORY HAS DELETED THIS HUMONGOUS CRIME OF MORE THAN ONE MILLION LEGITIMATE BABIES ( ANGLO INDIANS ) DELIVERED BY UNDERAGE GIRLS..
LIKE I SAID --
KARMA IS A BITCH..
WHAT HAPPENED?..
BRITISH WIVES OF THESE SOLDIERS FUCKED INDIAN LASCARS WHO WERE WAITING IN BRITISH PORTS FOR A TRIP BACK TO INDIA..
http://ajitvadakayil.blogspot.com/2010/05/lascar-original-indian-merchant-navy.html
THE WOMEN WHO COULD NOT GET AN INDIAN SAILOR WENT DOGGING..
WANNA KNOW WHAT IT IS?
GOOGLE FOR-- " DOGGING SEX UK " ( ONLY MEN ABOVE 18 PLEASE )..
WE DONT WANT PRION DISEASES..
PRIONS ARE HIDDEN IN THE BODY OF EVERY BRITISH MAN..
I KNOW HOW TO ACTIVATE PRIONS USING 5G .. I WONT TELL..
I WAS A SHIP CAPTAIN FOR 30 YEARS..
MY SHORE BOSSES TOOK SHIT FROM ME DAILY.. REASON?
MY PREDICTIONS WERE NEVER WRONG..
POOR JOHN BULLS DONT KNOW THAT QUEEN ELIZABETH 1 HAD A PRICK AND BALLS..
http://ajitvadakayil.blogspot.com/2014/12/exhumed-truths-of-spanish-armada-and.html
POOR JOHN BULLS DONT KNOW THAT THEIR KING EDWARD VIII ABDICATED HIS THRONE NOT FOR ROMANTIC LOVE -- BUT FOR GETTING HIS LUSTFUL ASSHOLE FUCKED BY HIS WIFE WALLIS SIMPSON ( WHO HAD A PRICK ) WHO COULD NOT BEAR CHILDREN..
http://ajitvadakayil.blogspot.com/2010/11/great-romance-and-curse-of-kohinoor.html
capt ajit vadakayil
..
PRION DISEASES OCCUR WHEN NORMAL PRION PROTEIN, FOUND ON THE SURFACE OF MANY CELLS, BECOMES ABNORMAL AND CLUMPS IN THE BRAIN, CAUSING BRAIN DAMAGE.
PRION DISEASES RESULT FROM MISFOLDING OF A NORMAL CELL-SURFACE BRAIN PROTEIN CALLED CELLULAR PRION PROTEIN (PRPC),. MISFOLDED PRION PROTEINS ARE CALLED PRIONS OR SCRAPIE PRP (PRPSC—FROM THE NAME OF THE PROTOTYPIC PRION DISEASE OF SHEEP).
PRIONS (PRPSC) ARE PATHOGENIC AND OFTEN INFECTIOUS. THEY PRODUCE PRION DISEASE BY SELF-REPLICATING: PRPSC INDUCES CONFORMATIONAL TRANSFORMATION OF PRPC, CREATING DUPLICATE PRPSC, WHICH, IN A CHAIN REACTION, INDUCES FURTHER TRANSFORMATION OF PRPC INTO PRPSC. THIS TRANSFORMATION PROCESS SPREADS PRPSC TO VARIOUS REGIONS OF THE BRAIN.
NORMAL PRPC IS WATER SOLUBLE AND PROTEASE SENSITIVE, BUT A LARGE PERCENTAGE OF PRPSC IS WATER INSOLUBLE AND MARKEDLY RESISTANT TO PROTEASE DEGRADATION (SIMILAR TO BETA-AMYLOID IN ALZHEIMER DISEASE, WHICH PRPSC RESEMBLES), RESULTING IN SLOW BUT INEXORABLE CELLULAR ACCUMULATION AND NEURONAL CELL DEATH.
ACCOMPANYING PATHOLOGIC CHANGES INCLUDE GLIOSIS AND CHARACTERISTIC HISTOLOGIC VACUOLAR (SPONGIFORM) CHANGES, RESULTING IN DEMENTIA AND OTHER NEUROLOGIC DEFICITS. IN ACQUIRED PRION DISEASES, SYMPTOMS AND SIGNS DEVELOP MONTHS TO YEARS AFTER THE INITIAL EXPOSURE TO PRPSC.
FAMILIAL PRION DISEASES ARE CAUSED BY DEFECTS IN THE PRP GENE, WHICH IS CONTAINED IN THE SHORT ARM OF CHROMOSOME 20.
CHROMOSOME 20 IS ONE OF THE 23 PAIRS OF CHROMOSOMES IN HUMANS. CHROMOSOME 20 SPANS AROUND 63 MILLION BASE PAIRS (THE BUILDING MATERIAL OF DNA) AND REPRESENTS BETWEEN 2 AND 2.5 PERCENT OF THE TOTAL DNA IN CELLS.
THE HUMAN PRION PROTEIN GENE (PRNP) IS LOCATED TO CHROMOSOME 20 (20P12-TER). MUTATIONS AND POLYMORPHISMS IN THE PRNP ARE ASSOCIATED WITH PRION DISEASE.
CHROMOSOME 20 LIKELY CONTAINS 500 TO 600 GENES THAT PROVIDE INSTRUCTIONS FOR MAKING PROTEINS. THESE PROTEINS PERFORM A VARIETY OF DIFFERENT ROLES IN THE BODY. THE PRNP GENE PROVIDES INSTRUCTIONS FOR MAKING A PROTEIN CALLED PRION PROTEIN (PRP), WHICH IS ACTIVE IN THE BRAIN AND SEVERAL OTHER TISSUES.
THE PRP GENE MUTATIONS ALTER THE AMINO ACID SEQUENCE OF PRPC, CAUSING IT TO MISFOLD AND BECOME PRPSC. PRPSC HAS THE SAME PRIMARY STRUCTURE AS PRPC BUT A DIFFERENT FOLD.
PRPC CAN UNDERGO CONVERSION INTO PRPSC THROUGH SPONTANEOUS MISFOLDING, A GENETIC MUTATION OF THE HUMAN PRNP GENE, OR EXPOSURE TO A PRION FROM AN EXTERNAL SOURCE.
TRANSMISSION FROM ANIMALS TO HUMANS HAS BEEN OBSERVED ONLY IN VCJD, AFTER PEOPLE CONSUMED BEEF FROM CATTLE WITH BOVINE SPONGIFORM ENCEPHALOPATHY (BSE, OR MAD COW DISEASE)..
ALTHOUGH PRION INFECTIONS DO NOT STIMULATE ADAPTIVE IMMUNE RESPONSES IN INFECTED INDIVIDUALS, THE ACTIONS OF CERTAIN IMMUNE CELL POPULATIONS CAN HAVE A SIGNIFICANT IMPACT ON DISEASE PATHOGENESIS.
AFTER INFECTION, THE TARGETING OF PERIPHERALLY-ACQUIRED PRIONS TO SPECIFIC IMMUNE CELLS IN THE SECONDARY LYMPHOID ORGANS (SLO), SUCH AS THE LYMPH NODES AND SPLEEN, IS ESSENTIAL FOR THE EFFICIENT TRANSMISSION OF DISEASE TO THE BRAIN.
ONCE THE PRIONS REACH THE BRAIN, INTERACTIONS WITH OTHER IMMUNE CELL POPULATIONS CAN PROVIDE EITHER HOST PROTECTION OR ACCELERATE THE NEURODEGENERATION.
A CHARACTERISTIC FEATURE OF THE PRION DISEASES IS THE ACCUMULATION OF PRPSC (ABNORMALLY FOLDED ISOFORMS OF THE MAMMALIAN HOST’S CELLULAR PRION PROTEIN, PRPC) IN AFFECTED TISSUES . THE ACCUMULATION OF PRPSC IN THE CENTRAL NERVOUS SYSTEM (CNS) ULTIMATELY LEADS TO THE DEVELOPMENT OF SPONGIFORM PATHOLOGY (VACUOLATION) AND NEURODEGENERATION.
A UNIQUE FEATURE OF THESE DISEASES WHEN COMPARED TO OTHER NEURODEGENERATIVE DISORDERS IS THEIR TRANSMISSIBILITY. PRION INFECTIVITY CO-PURIFIES WITH PRPSC IMPLYING THAT PRION PARTICLES ARE MOSTLY, IF NOT ENTIRELY, COMPRISED OF INFECTIOUS PROTEINS .
DURING PRION DISEASE, IMPORTANT POST-TRANSLATIONAL CHANGES OCCUR TO THE STRUCTURE OF THE PRPC MOLECULE THAT LEAD TO THE FORMATION OF PRPSC .
THESE CHANGES AFFECT THE PHYSICOCHEMICAL AND BIOLOGIC CHARACTERISTICS OF THE PRP MOLECULE, SUCH THAT PRION DISEASE-SPECIFIC PRPSC IS RELATIVELY RESISTANT TO PROTEINASE DIGESTION (WHEN COMPARED TO PRPC), CAN FORM INSOLUBLE AGGREGATES AND CAN INDUCE THE AUTOCATALYTIC CONVERSION OF FURTHER COPIES OF PRPC INTO PRPSC.
ALTHOUGH PRION INFECTIONS DO NOT INDUCE STRONG PRION-SPECIFIC IMMUNITY IN THE MAJORITY OF INFECTED INDIVIDUALS, THE INTERACTIONS BETWEEN THE PRIONS AND CERTAIN IMMUNE CELL POPULATIONS ARE ESSENTIAL FOR DISEASE DEVELOPMENT, WHEREAS INTERACTIONS WITH SOME IMMUNE CELLS CAN PROVIDE HOST PROTECTION. IN MAMMALS,
PRIONS REPRODUCE BY RECRUITING THE NORMAL, CELLULAR ISOFORM OF THE PRION PROTEIN (PRPC) AND STIMULATING ITS CONVERSION INTO THE DISEASE-CAUSING ISOFORM (PRPSC).
PRION DISEASES ARE CHARACTERIZED BY THE ACCUMULATION OF PRPSC, AN ABNORMALLY FOLDED ISOFORM OF THE CELLULAR PRION PROTEIN (PRPC), IN AFFECTED TISSUES. THE PATHOLOGY DURING PRION DISEASE APPEARS TO OCCUR ALMOST EXCLUSIVELY WITHIN THE CENTRAL NERVOUS SYSTEM.
THE EXTENSIVE NEURODEGENERATION WHICH OCCURS ULTIMATELY LEADS TO THE DEATH OF THE HOST. AN INTRIGUING FEATURE OF THE PRION DISEASES, WHEN COMPARED WITH OTHER PROTEIN-MISFOLDING DISEASES, IS THEIR TRANSMISSIBILITY.
FOLLOWING PERIPHERAL EXPOSURE, SOME PRION DISEASES ACCUMULATE TO HIGH LEVELS WITHIN LYMPHOID TISSUES. THE REPLICATION OF PRIONS WITHIN LYMPHOID TISSUE HAS BEEN SHOWN TO BE IMPORTANT FOR THE EFFICIENT SPREAD OF DISEASE TO THE BRAIN.
PRIONS REPLICATE DIRECTLY IN THEIR TARGET ORGAN, THE BRAIN, WHERE PRPC EXPRESSION LEVEL IS HIGHER.
CELLS WITHIN THE SLO / SECONDARY LYMPHOID ORGANS MAY ACTUALLY BE SITES OF PRION REPLICATION
PRION COLONIZATION OF SECONDARY LYMPHOID ORGANS (SLOS) IS A CRITICAL STEP PRECEDING NEUROINVASION IN PRION PATHOGENESIS.
PRIONS SPREAD FROM SLO TO THE BRAIN VIA THE PERIPHERAL NERVOUS SYSTEM
PRIONS SPREAD THROUGHOUT THE LYMPHATIC TISSUE AND THE ENTERIC NERVOUS SYSTEM, FINALLY REACHING THE CNS. THERE THEY INFECT THE NEURONS AND THEN ARE BROADCAST TO OTHER TISSUES FOR REPLICATION. THE PRION DISEASES WITH THIS TYPE OF TRANSMISSION HAVE A LONG INCUBATION PERIOD
A PRION (SHORT FOR PROTEINACEOUS INFECTIOUS PARTICLE) IS A UNIQUE TYPE OF INFECTIOUS AGENT, AS IT IS MADE ONLY OF PROTEIN.
THE SPLEEN HAS SOME IMPORTANT FUNCTIONS: IT FIGHTS INVADING GERMS IN THE BLOOD (THE SPLEEN CONTAINS INFECTION-FIGHTING WHITE BLOOD CELLS) IT CONTROLS THE LEVEL OF BLOOD CELLS (WHITE BLOOD CELLS, RED BLOOD CELLS AND PLATELETS) IT FILTERS THE BLOOD AND REMOVES ANY OLD OR DAMAGED RED BLOOD CELLS.
THIS PERIPHERAL PHASE OF PRION REPLICATION IN SLO SUCH AS THE SPLEEN WAS IMPORTANT FOR THE EFFICIENT TRANSMISSION OF DISEASE TO THE CNS.
PRIONS ARE INFECTIOUS PATHOGENS, PRIMARILY COMPOSED OF THE MISFOLDED FORM OF A PROTEIN CALLED PRP. NORMAL PRP MOLECULES THAT ARE CONVERTED INTO THE MISSHAPEN TYPE THEN AGGREGATE IN THE BRAIN TO FORM HARD, INSOLUBLE CLUMPS — WITH FATAL CONSEQUENCES.
PRIONS DON’T JUST REPLICATE IN THE BRAIN — THEY ALSO AFFECT LYMPHOID TISSUE, SUCH AS THE SPLEEN, TONSILS AND APPENDIX.
THE IMMUNE SYSTEM IS ESSENTIAL IN PROVIDING PROTECTION AGAINST INFECTIONS WITH MANY CONVENTIONAL PATHOGENS.
HOWEVER, QUITE THE OPPOSITE HAS BEEN SHOWN TO OCCUR IN ANIMALS INFECTED WITH PRIONS BY PERIPHERAL ROUTES OF EXPOSURE SUCH AS THE PERITONEAL CAVITY, BY SUBCUTANEOUS INJECTION OR VIA THE GASTROINTESTINAL TRACT.
THE SPLEEN CONTAINS MANY SPECIALIZED IMMUNE CELL POPULATIONS THAT ARE LOCALIZED IN SPECIFIC NICHES AND THESE PLAY AN IMPORTANT ROLE IN PROVIDING PROTECTION AGAINST SYSTEMIC PATHOGENS, AND THE REMOVAL OF THEIR ANTIGENS AND TOXINS FROM THE BLOOD-STREAM RATHER THAN PROVIDING HOST PROTECTION,
THE SPLEEN AND OTHER ELEMENTS OF THE IMMUNE SYSTEM MAY CONVERSELY PLAY AN IMPORTANT ROLE IN THE ESTABLISHMENT OF SOME PRION INFECTIONS.
PRIONS INVADE THE NERVOUS SYSTEM MOSTLY BY TRANSMIGRATION OF INFECTED LYMPHOID CELLS AS WELL AS RETROGRADE TRANSPORT IN ASCENDING PERIPHERAL TRACTS..
PRIONS FAIL TO ACTIVATE B CELLS WITH OR WITHOUT T CELL HELP.
PRION-SPECIFIC T CELLS ARE ABSENT DURING PRION INFECTION. OTHER INNATE IMMUNE RECEPTORS, LIKE CD21 OR TLRS, CAN PROVIDE SECONDARY SIGNALS WITHOUT T CELLS IN RESPONSE TO BACTERIA, BUT NOT TO PRIONS.
SCIENTISTS COULD NOT KILL THIS INFECTIOUS AGENT THE WAY ONE WOULD KILL VIRUSES OR BACTERIA. FOR INSTANCE, HEAT AND UV RADIATION KILL VIRUSES AND BACTERIA BY DESTROYING THEIR GENETIC MATERIAL, WHICH IS CRUCIAL TO THEIR EXISTENCE.
SPLENOCYTES CONSIST OF A VARIETY OF CELL POPULATIONS SUCH AS T AND B LYMPHOCYTES, DENDRITIC CELLS AND MACROPHAGES, WHICH HAVE DIFFERENT IMMUNE FUNCTIONS.
THE INFLAMMATORY RESPONSE IN PRION DISEASE OCCURS MOSTLY VIA THE ACTIVATION OF MICROGLIA, WHICH ARE THE IMMUNE CELLS OF THE CNS THAT ARE ACTIVATED IN RESPONSE TO INFECTION OR INJURY..
CNS PRION INFECTIONS ARE ACCOMPANIED BY EXTENSIVE MICROGLIAL AND ASTROCYTE ACTIVATION IN AFFECTED REGIONS ..
THE SPIKE PROTEIN AND ITS NUCLEIC ACID SEQUENCE MAY BE A COMPLEX BIOWEAPON CAPABLE OF INDUCING PRION DISEASE BY SEVERAL DIFFERENT MECHANISMS.
THE MRNA NUCLEIC ACID MAY CAUSE CERTAIN INTRINSIC PROTEINS LIKE TDP-43 AND FUS TO FOLD INTO PRIONS WHICH EVENTUAL LEADS TO DISEASE . THE SPIKE PROTEIN ALSO HAS A PRION LIKE REGION WHICH MAY CATALYZE A CHAIN REACTION AND EVENTUALLY LEAD TO PRION DISEASE.
THE SPIKE PROTEIN MAY CAUSE PROTEINS INCLUDING PRIONS ALREADY IN CELLS TO AGGREGATE, FORMING LEWY BODIES FOR EXAMPLE, AND CAUSING RELATIVELY RAPID CELL DEATH..
Α-SYNUCLEIN AGGREGATES IN THE SUBSTANTIA NIGRA OF THE BRAIN IN PARKINSON’S DISEASE PATIENTS CAUSING THE FORMATION OF LEWY BODIES.
LEWY BODIES TO PARKINSON DISEASE PROVIDES STRONG BIO PLAUSIBLE SUPPORT FOR A CAUSAL EFFECT WITH THIS SIGNAL BECAUSE INFECTIONS OF MONKEYS WITH THE SARS-COV-2 VIRUS LEAD TO DEVELOPMENT OF LEWY BODIES. THE RELATIVE RAPID ONSET OF PARKINSON’S DISEASE SYMPTOM AFTER IMMUNIZATION MAY BE EXPLAINED BY THE VACCINE DERIVED SPIKE PROTEIN’S HEPARIN BINDING SITE.
ONE GROUP SHOWED THAT THE SPIKE PROTEIN HEPARIN BINDING SITE BINDS “TO A NUMBER OF AGGREGATION-PRONE, HEPARIN BINDING PROTEINS INCLUDING AΒ, Α-SYNUCLEIN, TAU, PRION, AND TDP 43 RRM.
THESE INTERACTIONS SUGGESTS THAT THE HEPARIN-BINDING SITE ON THE S1 PROTEIN MIGHT ASSIST THE BINDING OF AMYLOID PROTEINS TO THE VIRAL SURFACE AND THUS COULD INITIATE AGGREGATION OF THESE PROTEINS AND FINALLY LEADS TO NEURODEGENERATION IN BRAIN.
THE ASTRAZENECA ADENOVIRAL VIRUS BASED COVID VACCINE MAY CONCENTRATE IN THE GASTROINTESTINAL SYSTEM TO A GREATER EXTENT LEADING TO FASTER TRANSPORT OF THE SPIKE PROTEIN VIA THE VAGUS NERVE TO THE BRAIN.
BY CONTRAST OVER THE LONG RUN THE PFIZER MRNA VACCINE MAY INDUCE MORE TDP-43 AND FUS TO FORM PRIONS AND LEAD TO MORE PRION DISEASE.
THE FOLDING OF TDP-43 AND FUS INTO THEIR PATHOLOGIC PRION CONFIRMATIONS IS KNOWN TO CAUSE ALS, FRONT TEMPORAL LOBAR DEGENERATION, ALZHEIMER’S DISEASE AND OTHER NEUROLOGICAL DEGENERATIVE DISEASES.
RNA BINDING PROTEINS HAVE MANY FUNCTIONS AND ARE FOUND IN BOTH THE NUCLEUS AND THE CYTOPLASM. THESE BINDING PROTEINS HAVE AMINO ACID REGIONS, BINDING MOTIFS THAT BIND SPECIFIC RNA SEQUENCES.
BINDING TO CERTAIN RNA SEQUENCES WHEN THE PROTEINS ARE IN THE CYTOPLASM IS BELIEVED TO CAUSES THE MOLECULES TO FOLD IN CERTAIN WAYS LEADING TO PATHOLOGIC AGGREGATION AND PRION FORMATION IN THE CYTOPLASM ,INDICATES PFIZER'S RNA BASED COVID-19 VACCINE CONTAINS MANY OF THESE RNA SEQUENCES THAT HAVE BEEN SHOWN TO HAVE HIGH AFFINITY FOR TDP-43 OR FUS AND HAVE THE POTENTIAL TO INDUCE CHRONIC DEGENERATIVE NEUROLOGICAL DISEASES.
PFIZER CORONAVIRUS VACCINE HAVE LONG TERM HEALTH EFFECTS NOT PREVIOUSLY DISCLOSED, INCLUDING “ALS, ALZHEIMER’S, AND OTHER NEUROLOGICAL DEGENERATIVE DISEASES‘.
MANY DNA- AND RNA-BINDING PROTEINS (RBPS) HAVE PRION-LIKE DOMAINS (PRLDS) DEFINED BY THEIR SIMILAR AMINO ACID COMPOSITIONS TO YEAST PRIONS MANY OF THESE RBPS, SUCH AS TDP-43, FUS, AND HNRNPA1, ALSO HAVE IDRS OR LCDS AND HAVE BEEN IMPLICATED IN NDS SUCH AS ALS AND FTD OTHER AMYLOIDOGENIC PROTEINS SUCH AS AMYLOID-Β (AΒ), TAU, AND Α-SYNUCLEIN (Α-SYN) HAVE SOME SIMILARITIES WITH PRIONS AND DRIVE SEVERAL NDS SUCH AS AD AND PD.
THE AMYLOID FOLD IS A VERY STABLE PROTEIN CONFORMATION, AND AS SUCH, AMYLOID IS GENERALLY RESISTANT TO DETERGENTS, HEAT DENATURATION, AND PROTEASE CLEAVAGE CONVERSION OF PROTEINS TO THE AMYLOID FOLD IS TYPICALLY DRIVEN BY AN AMYLOIDOGENIC REGION WITHIN THE PROTEIN, WHICH IS NECESSARY AND SUFFICIENT FOR FIBRILLIZATION .
CONVERSION TO THE AMYLOID FOLD IS IRREVERSIBLE. ONCE A SMALL AMOUNT OF PROTEIN ACCESSES THE AMYLOID FOLD, THIS SMALL QUANTITY OF PROTEIN CAN SERVE AS A TEMPLATE, NUCLEATING AND ACCELERATING THE CONVERSION OF REMAINING MONOMERIC PROTEIN TO THE AMYLOID FOLD .
PRIONS ARE DEFINED AS INFECTIOUS AMYLOIDS, BUT NOT ALL AMYLOIDOGENIC PROTEINS ARE CLASSIFIED AS PRIONS. PRION PROTEINS CAN SERVE FUNCTIONAL ROLES, BUT ALSO CAUSE SEVERAL DEVASTATING DISORDERS WHICH TYPICALLY AFFECT THE CENTRAL NERVOUS SYSTEM. A SALIENT FEATURE OF PRIONS IS THEIR INFECTIOUS NATURE, CHARACTERIZED AS THEIR ABILITY TO SPREAD OR PROPAGATE BETWEEN CELLS AND ORGANISMS.
PRIONS WERE FIRST RECOGNIZED AS NUCLEIC ACID FREE INFECTIOUS PARTICLES IN TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY (TSE).]. PRION SEEDS CAN SPONTANEOUSLY FORM FROM ALTERATIONS IN PROTEIN CONFORMATION, PERHAPS JUST DUE TO ORDINARY PROTEIN CONFORMATIONAL DYNAMICS.
CONVERSION TO THE PRION FORM CAN ALSO BE INDUCED BY EXTERNAL STIMULI, SUCH AS INOCULATION OF A SEED DIFFERENT CONFORMATIONS OF PRIONS CAN GIVE RISE TO DISTINCT PRION STRAINS WHICH CAN LEAD TO VARYING PHENOTYPES OF DISEASE,
LARGELY DUE TO DIFFERENCES IN NEURONAL VULNERABILITY VARIOUS STRAINS OF PRPSC GIVE RISE TO TSES IN HUMANS INCLUDING SPORADIC AND FAMILIAL CJD, FATAL FAMILIAL INSOMNIA, AND GERSTMANN-STRÄUSSLER-SCHEINKER DISEASE WHILE CJD CAN BE SPORADIC, FAMILIAL FORMS OF TSES ARE ASSOCIATED WITH SPECIFIC MUTATIONS IN THE PRP GENE THAT ACCELERATE ITS CONVERSION TO THE PRION CONFORMATION.
https://www.researchgate.net/publication/348363600_Evaluation_of_Ivermectin_as_a_Potential_Treatment_for_Mild_to_Moderate_COVID-19_A_Double-Blind_Randomized_Placebo_Controlled_Trial_in_Eastern_India
ALL AROUND THE PLANET
THOUSANDS OF MEDICAL STUDENTS ARE WRITING FABRICATED THESIS / PROJECTS
SUPPORTING THE JEWISH VACCINE LOBBY-- JUST FOR PERSONAL SELFISH GAINS.
capt ajit vadakayil
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IN ONE OF MY RELATIVES HOMES IN KANNUR
THEY EMPLOY A TAMILIAN MAID
HER HUSBAND COMES FOR FREE LUNCH..
AFTER THAT HE SLEEPS IN THE SHADE FOR AN HOUR BEFORE HE GOES BACK FOR WORK.. THIS BLOKE WAS A TOUGH GUY- LIKE TARZAN.
SO ONE DAY THE MAID DID NOT COME..
WHEN SHE WAS CONTACTED ON MOBILE PHONE-- SHE WAS CRYING..
HER HUSBAND WHO HAS TAKE COVISHIELD ( ASTRAZENECA ) VACCINATION-- WAS BED RIDDEN WITH BOTH LEGS INFLAMED AND SWOLLEN BELOW THE KNEES..
WHILE CRYING IN PAIN HE WAS REPEATING AGAIN AND AGAIN-- I HAVE NEVER FALLEN SICK IN MY LIFE-- THIS VACCINATION HAS CAUSED ALL THIS..
YOU THINK HE HAS A REDRESSAL MECHANISM IN INDIA ?
THIS IS WHY MODI CHOSE A GUJARATI HEALTH MINISTER -- WHO DOES NOT KNOW ENGLISH..
capt ajit vadakayil
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CAPT AJIT VADAKAYIL DECLARED ON 24TH JULY—THERE IS A NEW MAN MADE DISEASE CALLED “VACCINOSIS “—THIS mRNA VACCINE CAUSED DISEASE WILL BE THE MOST DEADLY DISEASE ON THE PLANET..
mRNA VACCINES LIKE PFIZER HAS ZERO EFFECT.. NOT 96% AS PFIZER BOASTS. GOD GIVEN NATURAL IMMUNITY SAVES NOT THE COVID VACCINE..
WOMEN WILL VOLUNTARILY REMOVE THEIR UTERUS UNABLE TO BEAR THE PAIN AND COPE WITH MONTHLY MENSTRUAL BLEEDING..
MEN WILL NOT MARRY – THEY DON’T WANT TO BE SADDLED WITH EXPENSES FOR DOWN SYNDROME BABIES.. MANY WILL BECOME HOMOSEXUALS..
AUTO IMMUNE DISEASES WILL SET THE PLANET ABLAZE..
WE HAVE COME OUT OF WORLD WAR TWO. THE PLANET WAS ABLAZE FOR SIX YEARS.. THE WOLRD WAS FIGHTING IN FAR FLUNG CORNERS OF THE PLANET—NOBODY KEW WHY.. NOBODY KNEW THAT HITLER WAS A JEW.
http://ajitvadakayil.blogspot.com/2020/05/vadakayil-backswing-rothschild-receding.html
GERMAN JEW ROTHSCHILD CONTROLLED BOTH SIDES OF THE WAR AND THE NEUTRAL NATIONS..
http://ajitvadakayil.blogspot.com/2018/02/britannia-did-not-rule-waves-and-this.html
ROTHSCHILD MILKED MOOLAH AND CARVED OUT THE STATE OF ISRAEL.
EVER HEARD OF KING GEORGE III WHO RULED FROM 1760 AD TO 1820 AD ( 60 LONG YEARS ) ? ROTHSCHILD TIED HIM TO HIS BED, WHERE HE WAS BEATED UP DAILY.. HE BODY WAS FULL OF SORES.
DURING THE REIGN OF KING GEORGE III , GERMAN JEW ROTHSCHILD CONDUCED THE AMERICAN WAR OF INDEPENDENCE / THE FRENCH REVOLUTION/ BATTLE OF WATERLOO..
WHO DO YOU THINK IS RULING AMERICA TODAY? SENILE OLD FAART JOE BIDEN? WHO DO YOU THINK HOLDS THE NUCLEAR FOOTBALL CODES?
WATCH REAGAN IN THE VIDEO BELOW—YOU WILL GET A HINT.
https://www.youtube.com/watch?v=QTcL6Xc_eMM
WHAT WAS THE ROOT CAUSE OF WW2? THE PROMISED LAND FOR THE CHOISEN PEOPLE, RIGHY?
ALL BASED ON A BULLSHIT STORY BY JEWESS HELENA IN 325 AD WHO COOKED UP MOSES ..
http://ajitvadakayil.blogspot.com/2018/12/helena-mother-of-roman-emperor.html
READ MY LATEST POST ON WHAT IS COMING IN FUTURE.
https://ajitvadakayil.blogspot.com/2021/07/welcome-to-real-dystopian-world-of.html
24TH JULY DEMONSTRATIONS AROUND THE PLANET..
AS USUAL INDIANS ARE THE NO 1 COWARDS.. THIS DESPITE CONING OUT OF 800 YEARS OF SLAVERY..
WE HAVE A TATU PM, WHO WORKS FOR HIS JEWISH MASTERS – NOT BHARATAMATA
https://www.youtube.com/watch?v=30lZGe5QYgI&t=1s
https://www.youtube.com/watch?v=wsB5yymbKXc
https://www.youtube.com/watch?v=WPgipKxq4d0&t=1s
https://www.youtube.com/watch?v=QxZg79DFXHE
https://www.youtube.com/watch?v=8VIPpZW2J_4
https://www.youtube.com/watch?v=o2OzK42BBDA
https://www.youtube.com/watch?v=QKJQvwhHBEg&t=1s
https://www.youtube.com/watch?v=1ffK9uE5vn0&t=1s
capt ajit vadakayil
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I HAD A CHIEF OFFICER ( INTELLIGENT MAN ) UNDER MY COMMAND HALF RUSSIAN/ HALF GERMAN FROM MURMANSK -- HE SAID USSR COMMUNISM FELL ONE MONTH AFTER THEY HAD FINALIZED A SINISTER PLAN THAT EVERY RESIDENTIAL FLAT COMPLEX WILL HAVE A BASEMENT KITCHEN , YOU HAVE TO EAT YOUR MEALS THERE COMPULSORILY..
TO BE CONTINUED --
CAPT AJIT VADAKAYIL
..
https://dailyexpose.co.uk/2021/07/27/the-vaccine-passport-a-one-way-ticket-to-communistic-tyranny/
COVID IS NOT A PANDEMIC.. PEOPLE WHO GOT ADMITTED IN HOSPITALS DIED.. PEOPLE WHO STAYED AT HOME SURVIVED..
https://ajitvadakayil.blogspot.com/2021/07/we-shall-celebrate-24th-july-2021-with.html
capt ajit vadakayil
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